ICPAL
3 rue du Professeur Laguesse
BP83 - 59006 - Lille Cedex
59000 - Lille
Tél. : +33 (0)3 20 96 49 04
Fax : +33 (0)3 20 96 49 06
Contact

2015

D. Baudelet, E. Lipka, R. Millet, A. Ghinet. Involvement of the P2X7 purinergic receptor in inflammation: an update of antagonists series since 2009 and their promising therapeutic potential. Curr. Med. Chem. (2015) 22, 713-729. IF [5.387]. doi: 10.2174/0929867322666141212120926#sthash.PJikYWgN.dpuf

V. Moas-Héloire, N. Renault, V. Batalha, A.R. Arias, M. Marchivie, S. Yous, N. Deguine, L. Buée, P. Chavatte, D. Blum, L. Lopes, P. Melnyk, L. Agouridas. Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines. Eur. J. Med. Chem. (2015) 106, 15-25. IF [3.447]. doi: 10.1016/j.ejmech.2015.10.030

P. Six, J.F. Goossens, W. Riquet, V. Brel, E. Fournier, J.P. Annereau, A. Kruczynski, O. Castillo-Aguilera, P. Depreux, C. Bailly, L. Goossens. Hemisynthesis of anisomycin derivatives as antitumor agents. Med. Chem. (2015) 11, 183-191. IF [1.39]. doi: 10.4172/2161-0444.1000262

T. Rogez-Florent, N. Azaroual, L. Goossens, J.F. Goossens, C. Danel. NMR investigation of the complexation and the chiral discrimination of diaryl-pyrazole sulfonamide  derivatives with cyclodextrins. Carbohydr. Polym. (2015) 115, 598-604. doi: 10.1016/j.carbpol.2014.09.046.

S. Ravez, S. Arsenlis, A. Barczyk, A. Dupont, R. Frédérick, S. Hesse, G. Kirsch, P. Depreux, L. Goossens. Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors. Bioorg. Med. Chem. (2015) 23, 7340-7347. IF [2.793]. doi:10.1016/j.bmc.2015.10.035

L. Lemaire, N. Leleu-Chavain, A. Tourteau, Alaa Abdul-Sada, J. Spencer, R. Millet. A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazoles. Tetrahedron Lett. (2015) 56, 2448-2450. IF [2.391]. doi:10.1016/j.tetlet.2015.03.082

D. Baudelet, C. Furman, A. Ghinet, X. Dezitter, S. Adriouch, F. Capet, T. Rogez-Florent, P. Gautret, B. Rigo, R. Millet, C. Vaccher, E. Lipka. Evaluation and comparison of three different separation techniques for analysis of retroamide enantiomers and their biological evaluation against h-P2X7 receptor. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2015) 1, 986-987. IF [2.694]. doi: 10.1016/j.jchromb.2015.02.001

N. Kambia, A. Farce, K. Belarbi, B. Gressier, M. Luyckx, P. Chavatte, T. Dine. Docking study: PPARs interaction with the selected alternative plasticizers to di(2-ethylhexyl) phthalate. J. Enzyme Inhib. Med. Chem. (2015) 1-8. IF [2.383]. doi:10.3109/14756366.2015.1037748

S. Ravez, N. Schifano-Faux, A. Barczyk, S. Arsenlis, B. Baldeyrou, O. Castillo Aguilera, A. Lansiaux,  P. Six, J.-F. Goossens, P. Depreux, L. Goossens. Synthesis and antiproliferative activity of 2-amino-4-anilinoquinazoline derivatives. Med. Chem. (2015) 5, 67-76. IF [1.39]. doi:10.4172/2161-0444.1000245

S. Ravez, O. Castillo Aguilera, P. Depreux, L. Goossens. Quinazoline derivatives as anticancer drugs: a patent review (2011 – present). Expert Opin. Ther. Pat. (2015) 25, 789-804. IF [3.44]. doi:10.1517/13543776.2015.1039512

P.E. Larchanche, V. Ultré, D. Le Broc, C. Ballandone, C. Furman, P. Dallemagne, P. Melnyk, P. Carato. 6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands. Eur. J. Med. Chem. (2015) 92, 807-817. IF [3.447]. doi: 10.1016/j.ejmech.2015.01.052

M. Donnier-Maréchal, P. Carato, D. Le Broc, C. Furman, P. Melnyk. Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands. Eur. J. Med. Chem. (2015) 92, 575-582. IF [3.447]. doi: 10.1016/j.ejmech.2014.01.013

M. Donnier-Maréchal, P.E. Larchanché, D. Le Broc, C. Furman, P. Carato, P. Melnyk. Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands. Eur. J. Med. Chem. (2015) 89, 198-206. IF [3.447]. doi: 10.1016/j.ejmech.2014.10.053

2014

J. El Bakali., G.G. Muccioli, M. Body-Malapel, M. Djouina, F. Klupsch, A. Ghinet, A. Barczyk, N.  Renault, P. Chavatte, P. Desreumaux, D.M. Lambert, R. Millet. Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis. ACS Med. Chem. Lett. (2014) 6, 198-203. IF [3.073]. doi: 10.1021/ml500439x

X. Laurent, N. Renault, A. Farce, P. Chavatte, E. Hénon. Relationships between Th1 or Th2 iNKT cell activity and structures of CD1d-antigen complexes: meta-analysis of cd1d-glycolipids dynamics simulations. PLOS Comput. Biol. (2014) 10, 1-15. IF [5.215]. doi: 10.1371/journal.pcbi.1003902

D. Baudelet, N. Schifano-Faux, A. Ghinet, X. Dezitter, F. Barbotin, P. Gautret, B. Rigo, P. Chavatte, R. Millet, C. Furman, C. Vaccher, E. Lipka. Enantioseparation of pyroglutamide derivatives on polysaccharide based chiral stationary phases by high-performance liquid chromatography and supercritical fluid chromatography: A comparative study. J. Chromatogr. A (2014) 1363, 257-259. IF [4.339]. doi: 10.1016/j.chroma.2014.06.090

N. Azaroual, J. El Bakali, D. Le Broc-Ryckewaert, J.P. Bonte, A. Farce, P. Chavatte, R. Millet, C. Vaccher, E. Lipka-Belloli. NMR studies of interactions of new CB2 agonists derivatives with cyclodextrins hosts. Correlation with Micellar Electrokinetic Chromatography and High Performance Liquid Chromatography. J. Incl. Phenom. Macrocycl. Chem. (2014) 78, 265-274.  IF [1.270]

D. Baudelet, A. Ghinet, C. Furman, X. Dezitter, P. Gautret, B. Rigo, R. Millet, E. Lipka. Antagonists of the P2X7 receptor: mechanism of enantioselective recognition using highly sulfated CDs in electrokinetic chromatography. Electrophoresis (2014) 35, 2892-2899. IF [3.609]. doi: 10.1002/elps.201400113

N. Leleu-Chavain, P. Chavatte, P. Desreumaux, R. Millet. Therapeutical potential of CB2 receptors in immune-related diseases. Curr. Mol. Pharm. (2014) 6, 183-203. IF [4.44]. doi: 10.2174/1874467207666140219122337

A. Tourteau, N. Leleu-Chavain, M. Body-Malapel, V. Andrzejack, A. Barczyk, M. Djouina, B. Rigo, P. Desreumaux, P. Chavatte, R. Millet. Switching cannabinoid response from CB2 agonists to FAAH inhibitors. Bioorg. Med. Chem. Lett. (2014) 24, 1322-1326. IF [2.589]. doi: 10.1016/j.bmcl.2014.01.056

X. Laurent, N. Renault, A. Farce, B. Bertin, S. Speca, O. Milhomme, R. Millet, P. Desreumaux, E. Henon, P. Chavatte. Switching iNKT response from anti-cancerous to anti-inflammatory effect: molecular bases. J. Med. Chem. (2014) 57, 5489-5508. IF [5.207]. doi: 10.1021/jm4010863

T. Rogez-Florent, L. Duhamel, L. Goossens, P. Six, A. Drucbert, P. Depreux, P.M. Danze, D. Landy, J.F. Goossens, C. Foulon. Label-free characterization of carbonic anhydrase – novel inhibitors interactions using surface plasmon resonance, isothermal titration calorimetry and fluorescence-based thermal shift assays. J. Mol. Recog. (2014), 27, 46–56. IF [3.31]. doi: 10.1002/jmr.2330

S. Ravez, A. Barczyk,  P. Six, A. Cagnon, A. Garofalo, L. Goossens, P. Depreux. Inhibition of tumor cell growth and angiogenesis by 7-aminoalkoxy-4-aryloxy-quinazoline ureas, a novel series of multi-tyrosine kinase inhibitors. Eur. J. Med. Chem. (2014) 79, 369-381. IF [3.34]. doi: 10.1016/j.ejmech.2014.04.007

2013

A. Tourteau, V. Andrzejak, M. Body-Malapel, L. Lemaire, A. Lemoine, R. Mansouri, M. Djouina, N. Renault, J. El Bakali, P. Desreumaux, G.G. Muccioli, D.M. Lambert,  P. Chavatte, B. Rigo, N. Leleu-Chavain, R. Millet. 3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis. Bioorg. Med. Chem. (2013) 21, 5383-5394. IF [3.108]. doi: 10.1016/j.bmc.2013.06.010

N. Leleu-Chavain, C. Biot, P. Chavatte, R. Millet. From cannabis to selective CB2 agonists: molecules with numerous therapeutical virtues. Med. Sci.: m/s (2013) 29, 523-528 IF [1.543]. doi: 10.1051/medsci/2013295016

N. Azaroual, J. El Bakali, D. Le Broc-Ryckewaert, J.P. Bonte, A. Farce, P. Chavatte, R. Millet, C. Vaccher, E. Lipka-Belloli. NMR studies of interactions of new CB2 agonists derivatives with cyclodextrins hosts. Correlation with Micellar Electrokinetic Chromatography and High Performance Liquid Chromatography. J. Incl. Macrocycl. Phenom. (2013) 78, 265-274. IF [1.426]. doi: 10.1007/s10847-013-0295-0

V. Stocker, A. Ghinet, M. Leman, B. Rigo, R. Millet, A. Farce, D. Desravines, J. Dubois, C. Waterlot, P. Gautret. On the synthesis and biological properties of isocombretastatins: a case of ketone homologation during a Wittig reaction attempt. RSC Advances (2013) 3, 3683-3696. IF [3.041]. doi: 10.1039/C2RA22391K

 

A. Karamitri, N. Renault, N. Clement, J.L. Guillaume, R. Jockers. Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes. Mol. Endocrinol. (2013) 27:1217-1233. doi: 10.1210/me.2013-1101.

N. Renault, X. Laurent, A. Farce, J. El Bakali, R. Mansouri, R. Millet, P. Desreumaux. C. Furman, P. Chavatte. Identification of novel CB2 receptor agonists from structure-based virtual screening: structural insights into agonist-bound GPCR features. Chem. Biol. Drug Des. (2013) 81, 442-454. IF [2.683]. doi: 10.1111/cbdd.12095

 

V.Moas Heloire, C. Furman, R. Mansouri, P. Carato. Synthesis of 6-substituted sulfonylimidazopyridines as potent 5-HT6 receptor antagonists. Monat. Chem. (2013) 144, 429-435. IIF [1.312]. doi: 10.1007/s00706-012-0893-3

D. Le Broc-Ryckewaert, R. Carpentier, E. Lipka, S. Daher, C. Vaccher, D. Betbeder, C. Furman. Development of innovative Paclitaxel-loaded small PLGA nanoparticles : study of their antiproliferative activity and their molecular interactions on prostatic cancer cells. Int. J. Pharm. (2013) 454, 712-719. IF [3.272]. doi: 10.1016/j.ijpharm.2013.05.018

T. Rogez-Florent, S. Meignan, C. Foulon, P. Six,  A. Gros, C. Bal-mahieu, C. Supuran, A. Scozzafava, R. Frederick, B. Masereel, P. Depreux, A. Lansiaux, J.F. Goossens, S. Gluszok, L. Goossens. New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides. Bioorg. Med. Chem. (2013) 21, 1451-1464. IF [2.624]. doi: 10.1016/j.bmc.2012.10.029

 

2012

V. Gembus, C. Furman, R. Millet, R. Mansouri, P. Chavatte, V. Levacher, J.-F. Brière. Scaffold hopping strategy towards pyrazolines as selective CB2 receptor ligands. Eur. J. Med. Chem. (2012) 58, 396-404 IF [3.356]. doi: 10.1016/j.ejmech.2012.10.031

J. El Bakali, P. Gilleron, M. Body-Malapel, M. Roxane, G.G. Muccioli, M. Djouina,  A. Barczyk, F. Klupsch,  V. Andrzejak-Lucas, E. Lipka, C. Furman, D. M. Lambert, P. Chavatte, P. Desreumaux, R. Millet. 4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands. Part 2: Toward new therapeutic agents in the treatment of colitis. J. Med. Chem. (2012) 55, 8948-8952. IF [5.207]. doi: 10.1021/jm3008568

N. Leleu-Chavain, M. Body-Malapael, J. Spencer, P. Chavatte, P. Desreumaux, R. Millet. Recent advances in the development of selective CB2 agonists as promising anti-inflammatory agents. Curr. Med. Chem. (2012) 19, 3457-3474. IF [5.387]. doi: 10.2174/092986712801323207

J. Spencer, H. Patel, J.J. Deadmand, J. Amin, S.K. Callear, S.J. Coles, C. Furman, R. Mansouri, P. Chavatte, R. Millet. Microwave mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. Tetrahedron Lett. (2012) 53, 1656-1659. IF [2.483]. doi: 10.1016/j.tetlet.2012.01.081

C. Pirat, A. Farce, N. Lebègue, N. Renault, C. Furman, R. Millet, S. Yous, S. Speca, P. Berthelot, P. Desreumaux, P. Chavatte. Targeting PPARs: development of modulators. J. Med. Chem. (2012) 55, 4027-4061. IF [5.173]. doi: 10.1021/jm101360s

A. Garofalo, A. Farce, S. Ravez, A. Lemoine, P. Six, P. Chavatte, L. Goossens, P. Depreux. Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.  J. Med. Chem. (2012) 55, 1189-1204. IF [5.173]. doi: 10.1021/jm2013453

R. Akué-Gédu, D. Couturier, J.-P. Hénichart, B. Rigo, G. Sanz, L Van Hijfte, A. Bourry. Studies on Pyrrolidinones. Synthesis of 4,5-fused-3-hydroxypyridinyl-2-propionic acid derivatives. Tetrahedron (2012) 68, 1117-1127. IF [3.041]. doi: 10.1016/j.tet.2011.11.071

R. Akué-Gédu, D. Couturier, J.-P. Hénichart, B. Rigo, G. Sanz, L. Van Hijfte, A. Bourry. Studies on pyrrolidinones. Synthesis of fused 1, 5-naphthyridines. Tetrahedron (2012) 68, 5644-5664. IF [3.041]. doi: 10.1016/j.tet.2012.04.056

A. Ghinet, A. Farce, S. Oudir, J. Pommery, J. Vamecq, J.-P.Hénichart, B. Rigo, P. Gautret. Antioxidant activity of new benzo[de]quinolines and lactams: quantitative structure-activity relationships. Med. Chem. (2012), 8, 842-846. IF [1.642]. doi: 10.2174/157340612802084216

A. Ghinet, P. Gautret, J. Dubois, A. Farce, J-P Hénichart, B Rigo. Discovery of ferrocene-containing farnesyltransferase inhibitors. Investigation of bulky lipophilic groups for the A2 binding site of farnesyltransferase. Med. Chem. Commun. (2012) 3, 1147-1154. IF [2.800]. doi: 10.1039/c2md20138k

E. Lipka, S. Yous, C. Furman, P. Carato, C. Deghaye, J.P. Bonte, C. Vaccher. Analytical and Preparative Chiral Separation of b-Carboline Derivatives, LDL Oxidation Inhibitors, Using HPLC and CE Methodologies. Determination of Enantiomeric Purity. Chromatographia (2012) 75, 337-345. IF [1.186] doi: 10.1007/s10337-012-2194-8

A. Garofalo, A. Farce, S. Ravez, A. Lemoine, P. Six, P. Chavatte, L. Goossens,  P. Depreux. Synthesis and Structure−Activity Relationships of Aryloxy-Quinazoline Urea as   Novel,   Potent,   and   Selective   Vascular   Endothelial Growth Factor Receptor-2 Inhibitors. J. Med. Chem. (2012) 55, 1189−1204. IF [5.24]. doi: 10.1021/jm2013453<xml></xml>

2011

V. Andrzejak, G.G. Muccioli, M. Body-Malapel, N. Renault, M. Djouina, J. El Bakali,  P. Desreumaux, P. Chavatte, D.M. Lambert, R. Millet. New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis. Bioorg. Med. Chem. (2011) 19, 3777-3786. IF [3.046]. doi: 10.1016/j.bmc.2011.04.057

N. Wlodarczyk, D. Ryckewaert, P. Gilleron, A. Lemoine, A. Farce, P. Chavatte, J. Dubois, N. Pommery, J.P. Hénichart, C. Furman, R. Millet. Design, synthesis of novel farnesyltransferase inhibitors with 1,4-diazepane scaffold as novels microtubule-destabilizing agent in PC3 cells. J. Med. Chem. (2011) 54, 1178-1190. IF [5.173]. doi: 10.1021/jm101067y.

C.L. Lino Cardenas, N. Renault, A. Farce, C. Cauffiez, D. Allorge, J.M. Lo-Guidice, M. Lhermitte, P. Chavatte, F. Broly, D. Chevalier. Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population. Gene (2011) 487, 10-20. IF [2.704]. doi: 10.1016/j.gene.2011.07.015

A. Garofalo, L. Goossens, P. Six, A. Lemoine, S. Ravez, A. Farce, P. Depreux.  Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors. Bioorg. Med. Chem. Lett. (2011) 21, 2106-12. IF [2.592]. doi: 10.1016/j.bmcl.2011.01.137

T. Boisse, L. Gavara, P. Gautret, B. Baldeyrou, A. Lansiaux J.-F. Goossens, J.-P. Hénichart,  B. Rigo. Toward new camptothecins. Part 7: Synthesis of thioluotonine and his 5-methoxycarbonyl derivative. Tetrahedron Lett. (2011) 52, 1592-1596. IF [3.041]. doi: 10.1016/j.tetlet.2011.01.105

A. Ghinet, B. Rigo, J.-P. Hénichart, D. Le Broc-Ryckewaert, J. Pommery, N. Pommery, X. Thuru, B. Quesnel, P. Gautret. Synthesis and biological evaluation of phenstatin metabolites. Bioorg. Med. Chem. (2011) 19, 6042–6054. IF [3.046]. doi: 10.1016/j.bmc.2011.08.047

D. Le Broc-Ryckewaert, N. Pommery, J. Pommery, A. Ghinet, A. Farce, J.-F. Wiart, P. Gautret, B. Rigo, J.-P. Hénichart. In vitro metabolism of phenstatin: potential pharmacological consequences. Drug Met. Lett. (2011) 5, 209-215. IF [1.699]. doi: 10.2174/187231211796904973

A. Garofalo, L. Goossens, N. Lebegue, P. Depreux. A novel and efficient one-pot synthesis of (aminophenyl)carbamic acid esters”. Synth. Comm. (2011) 41, 2007- 2016. IF [1.02]. doi: 10.1080/00397911.2010.494818

E. Stern, L. Goossens, P. Retailleau, F. Kauffmann, J-P. Bonte, P. Depreux, J-F. Goossens. Preparative enantiomeric separation of new selective CB2 receptor agonists by liquid chromatography on polysaccharide-based chiral stationary phases: determination of enantiomeric purity and assignment of absolute stereochemistry by X-ray structure analysis. Chirality. (2011), 23, 389-396. IF [2.35]. doi: 10.1002/chir.20939

A. Garofalo, L. Goossens, A. Lemoine, S. Ravez, P. Six, A. Farce, P. Depreux. [4-(6,7-Disubstituted quinazolin-4-ylamino)phenyl] carbamic acid esters: a novel series of dual EGFR/VEGFR-2 tyrosine kinase inhibitors. Med. Chem. Comm. (2011), 2, 65-75. IF [2.722]. doi: 10.1039/c0md00183j

A. Garofalo, L. Goossens, P. Six,  A. Lemoine, S. Ravez, A. Farce, P. Depreux. Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors. Bioorg. Med. Chem. Letters. (2011), 21, 2106-2112. IF [2.554]. doi: 10.1016/j.bmcl.2011.01.137

2010

V. Andrzejak, R. Millet, J. El Bakali, A. Guelzim, S. Gluszok, P. Chavatte, J.-P. Bonte, C. Vaccher, E. Lipka. Synthesis of 2,3 and 4,5-dihydro-hydroxy-isoxazoles and isoxazoles under different pH conditions. Lett. Org. Chem. (2010) 7, 32-38. IF [0.911]. doi: 10.2174/157017810790533922

S. Welti, P.A. Moreau, N. Azaroual, C. Decock, A. Lemoine, N. Duhal, M. Kouach, R. Millet, R. Courtecuisse. Antiproliferative Activities of Methanolic Extracts from a Neotropical Ganoderma Species (Aphyllophoromycetideae): Identification and Characterization of a Novel Ganoderic Acid. Int. J. Med. Mushrooms (2010) 12, 17-31. IF [0.661]. doi: 10.1615/IntJMedMushr.v12.i1.20

A. Bridoux, R. Millet, J. Pommery, N. Pommery, J.P. Hénichart. Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg. Med. Chem. (2010) 18, 3910-3924. IF [3.046]. doi: 10.1016/j.bmc.2010.04.034

J. El Bakali, G.G. Muccioli, N. Renault, D. Pradal, M. Body-malapel, M. Djouina, L. Hamtiaux, V. Andrzejak, P. Chavatte, P. Desreumeaux, D.M. Lambert, R. Millet. 4-Oxo-1,4-dihydropyridines as selective CB2 receptor ligands: Structural insights into the design of a novel inverse agonist series. J. Med. Chem. (2010) 53, 7918-7931. IF [5.173]. doi: 10.1021/jm100286k

A. Ghinet, S. Oudir, J.-P. Hénichart, B. Rigo, N. Pommery, P. Gautret. Studies on Pyrrolidinones. On the application of copper catalyzed arylation of methyl pyroglutamate to obtain a new benzo[de]quinoline scaffold. Tetrahedron (2010) 66, 215-221. IF [3.041]. doi: 10.1016/j.tet.2009.10.103

L. Gavara, T. Boisse, J.-P. Hénichart, A. Daïch, B. Rigo. Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction. Tetrahedron (2010) 66, 7544-7561. IF [3.041]. doi: 10.1016/j.tet.2010.07.048

N. Renault, A. Gohier, P. Chavatte, A. Farce. Novel structural insights for drug design of selective 5-HT(2C) inverse agonists from a ligand-biased receptor model. Eur. J. Med. Chem. (2010) 45, 5086-5099. IF [3.363]. doi: 10.1016/j.ejmech.2010.08.018

A. Garofalo, L. Goossens, A. Lemoine, A. Farce, Y. Arlot, P. Depreux. Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer. J. Enzyme Inhib. Med. Chem. (2010) 25, 158-171. IF [1.724]. doi: 10.3109/14756360903169485

L. Peyrin-Biroulet, J. Beisner, G. Wang, S. Nuding, S. Thottathil Oommen, D. Kelly, E. Parmentier-Decrucq, R. Dessein, E. Merour, P. Chavatte, T. Grandjean, A. Bressenot, P. Desreumaux, J.-F. Colombel, B. Desvergne, E. F. Stange, J. Wehkamp, M. Chamaillard. PPARg activation is required for maintenance of innate antimicrobial immunity in the colon. PNAS (2010) 107, 8772-8777. IF [10.591]. doi: 10.1073/pnas.0905745107

A. Mésangeau, B. Pérès, C. Descamps-François, P. Chavatte, V. Audinot, S. Coumailleau, J.-A. Boutin, P. Delagrange, C. Bennejean, P. Renard, P. Berthelot, S. Yous. Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as Selective MT1 melatoninergic ligands. Bioorg. Med. Chem. (2010) 18, 3426-3436. IF [3.046]. doi: 10.1016/j.bmc.2010.04.008

A. Garofalo, L. Goossens, A. Lemoine, A. Farce, Y. Arlot,  P. Depreux. Quinazoline–urea, new protein kinase inhibitors in treatment of prostate cancer. J. Enzym. Inhib. Med. Chem. (2010) 25, 158-171. IF [1.63]. doi: 10.3109/14756360903169485

M. Mimeault, S.L. Johansson, E. Moore, J.P. Henichart, P. Depreux, S.K. Batra. Cytotoxic effects induced by docetaxel, gefitinib and cyclopamine on SP and non-SP cell fractions from human tumorigenic and invasive prostate cancer cells. Mol. Cancer Ther. (2010) 9, 617-630. IF [5.13]. doi: 10.1158/1535-7163.MCT-09-1013

S. Gluszok, R. Frédérick, Cl.T. Supuran, B. Masereel, P. Depreux, L. Goossens. Design, solid-phase synthesis and biological evaluation of novel 1,2-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors. Bioorg. Med. Chem. (2010) 18, 7392-7401. IF [2.624]. doi: 10.1016/j.bmc.2010.09.007

A. Garofalo, L. Goossens, A. Lansiaux, B. Baldeyroux, A. Lemoine, S. Ravez, M-H. David, P. Six, P. Depreux, J–F. Goossens. Design, synthesis and DNA–binding of N-methyl(anilino)quinazoline derivatives. J. Med. Chem. (2010) 53, 8089-8103. IF [5.24]. doi: 10.1021/jm1009605

 

F. Bienaime, M.A. Dragon-Durey, C.H. Regnier, S.C. Nilsson, W.H. Kwan, J. Blouin, M. Jablonski, N. Renault, M.A. Rameix-Welti, C. Loirat, C. Sautes-Fridman, B.O. Villoutreix, A.M. Blom, V. Fremeaux-Bacchi. Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome. Kidney Int. (2010) 77, 339-349. doi: 10.1038/ki.2009.472